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A global transcriptional analysis of Megalobrama amblycephala revealing the molecular determinants of diet-induced hepatic steatosis
文献类型:期刊论文
作者:Zhang, Dingdong[1]  Lu, Kangle[2]  Jiang, Guangzhen[3]  Liu, Wenbin[4]  Dong, Zaijie[5]  Tian, Hongyan[6]  Li, Xiangfei[7]  
机构排名:[1]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Peoples R China.;
[2]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;
[3]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;
[4]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;
[5]Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Peoples R China.;
[6]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;
[7]Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.;
通讯作者:Liu, WB (reprint author), Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, Nanjing 210095, Jiangsu, Peoples R China.
年:2015
期刊名称:GENE影响因子和分区
卷:570
期:2
页码范围:255-263
增刊:正刊
收录情况:SCI(E)(WOS:000360511100013)  
所属部门:淡水渔业研究中心;罗非鱼和鲤鱼遗传育种创新团队
语言:外文
ISSN:0378-1119
被引频次:8
人气指数:566
浏览次数:566
基金:Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization of the Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences [KF201310]; China Agriculture Research System [CARS-46-20]; "333" Projects of Jiangsu Province
关键词:Megalobrama amblycephala; Hepatic steatosis; High-fat diet; RNA-Seq; Digital gene expression
摘要:
Blunt snout bream (Megalobrama amblycephala), a prevalent species in China's intensive polyculture systems, is highly susceptible to hepatic steatosis, resulting in considerable losses to the fish farming industry. Due to a lack of genomic resources, the molecular mechanisms of lipid metabolism in M. amblycephala are poorly understood. Here, a hepatic cDNA library was generated from equal amounts of mRNAs isolated from M. amblycephala fed normal-fat and high-fat diets. Sequencing of this library ...More
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