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PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
外文标题:PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
文献类型:期刊论文
作者:Feng Yue[1]  Changyou Song[1]  Di Huang[3]  Naagarajan Narayanan[4]   Jiamin Qiu[5]  Zhihao Jia[6]  Zhengrong Yuan[7]  Stephanie N. Oprescu[8]  Bruno T. Roseguini[9]  Meng Deng[10]  Shihuan Kuang[11]  
机构排名:1 Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; 2 Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA; 3 Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA; 4 Department of Health and Kinesiology, Purdue University, West Lafayette, IN 47907, USA; 5 Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
年:2021
期刊名称:Molecular Therapy影响因子和分区
卷:29
期:1
页码范围:132-148
增刊:正刊
所属部门:淡水渔业研究中心;大宗淡水养殖动物营养与饲料创新团队
重要成果类型:ESI热点
语言:外文
人气指数:272
浏览次数:272
关键词:Phosphatase and tensin homolog; skeletal muscle; degenerative disease; membrane repair; MG53
摘要:
Duchenne Muscular Dystrophy (DMD) is a lethal degenerative muscle disease with no cure. Here we report that skeletal muscle-specific knockout (KO) of Pten gene in an animal model of DMD (mdx mice) alleviates myofiber degeneration and restores muscle function without increasing tumor incidences. Specifically, Pten KO normalizes myofiber size and prevents muscular atrophy, and improves grip strength and exercise performance of mdx mice. Pten KO also reduces fibrosis and inflammation; and ameliorat ...More
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