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Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos
文献类型:期刊论文
作者:Yuan, Lilai[1]  Qian, Le[2]  Qian, Yu[3]  Liu, Jia[4]  Yang, Ke[5]  Huang, Ying[6]  Wang, Chengju[7]  Li, Yingren[8]  Mu, Xiyan[9]  
机构排名:[1]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[2]China Agr Univ, Coll Sci, Beijing 100193, Peoples R China.;
[3]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[4]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[5]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[6]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[7]China Agr Univ, Coll Sci, Beijing 100193, Peoples R China.;
[8]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
[9]Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.;
通讯作者:Mu, XY (reprint author), Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China.
年:2019
期刊名称:ENVIRONMENTAL SCIENCE & TECHNOLOGY影响因子和分区
卷:53
期:24
页码范围:14638-14648
增刊:正刊
收录情况:SCI(E)(WOS:000503910500060)  中文核心期刊要目总览  
语言:外文
ISSN:0013-936X
人气指数:5
浏览次数:5
基金:National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21607173]; Young Elite Scientists Sponsorship Program by CAST [2018QNRC001]; Central Public-interest Scientific Institution Basal Research Fund, CAFS [2017HYZD0201]
摘要:
In this study, the influence of bisphenol F (BPF) toward central nervous system (CNS) was assessed using zebrafish embryos. We found that BPF could induce significant neurotoxicity toward zebrafish embryos, including inhibited locomotion, reduced moving distance, and CNS cell apoptosis at an effective concentration of 0.0005 mg/L. Immunofluorescence assay showed that both microglia and astrocyte in zebrafish brain were significantly activated by BPF, indicating the existence of neuroinflammatory ...More
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