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Involvement of the PI3K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication
文献类型:期刊
作者:Huang, Xiaohong[1]  Wang, Wei[2]  Huang, Youhua[3]  Xu, Liwen[4]  Qin, Qiwei[5]  
机构:[1]Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,Univ Chinese Acad Sci, Beijing, Peoples R China.;
[2]Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,Univ Chinese Acad Sci, Beijing, Peoples R China.;
[3]Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,Univ Chinese Acad Sci, Beijing, Peoples R China.;
[4]Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510300, Guangdong, Peoples R China.;
[5]Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,Univ Chinese Acad Sci, Beijing, Peoples R China.;
通讯作者:Qin, QW (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
年:2014
期刊名称:FISH & SHELLFISH IMMUNOLOGY影响因子和分区
卷:41
期:2
页码范围:371-379
增刊:正刊
收录情况:SCI(E)(WOS:000347017500031)  
所属部门:黄海水产研究所;南海水产研究所
语言:外文
ISSN:1050-4648
被引频次:9
人气指数:1465
浏览次数:1465
基金:National Natural Science Foundation of China [31372566, 31172437, 31172445]; National Basic Research Program of China (973) [2012CB114402, 2012CB114404]
关键词:Largemouth bass; LMBV; Apoptosis; PI3K signaling pathway; ERK signaling pathway
摘要:
Increased reports demonstrated that largemouth Bass, Micropterus salmoides in natural and artificial environments were always suffered from an emerging iridovirus disease, largemouth Bass virus (LMBV). However, the underlying mechanism of LMBV pathogenesis remained largely unknown. Here, we investigated the cell signaling events involved in virus induced cell death and viral replication in vitro. We found that LMBV infection in epithelioma papulosum cyprini (EPC) cells induced typical apoptosis, ...More
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