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Identification and expression of the hepcidin gene from brown trout (Salmo trutta) and functional analysis of its synthetic peptide
文献类型:期刊
作者:Huang, Tianqing[1]  Gu, Wei[2]  Wang, Bingqian[3]  Zhang, Yuyong[4]  Cui, Lili[5]  Yao, Zuochun[6]  Zhao, Cheng[7]  Xu, Gefeng[8]  
机构:[1]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[2]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[3]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[4]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[5]Yunnan Acad Fishery Sci, Kunming, Yunnan, Peoples R China.,Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Yunnan, Peoples R China.;
[6]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[7]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
[8]Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China.;
通讯作者:Xu, GF (reprint author), Heilongjiang River Fisheries Res Inst, HeSong St 232, Harbin 150070, Heilongjiang, Peoples R China.
年:2019
期刊名称:FISH & SHELLFISH IMMUNOLOGY影响因子和分区
卷:87
页码范围:243-253
增刊:正刊
收录情况:SCI(E)(WOS:000464086600028)  
所属部门:黑龙江水产研究所
语言:外文
ISSN:1050-4648
人气指数:48
浏览次数:47
基金:China Agriculture Research System [CARS-46]
关键词:Brown trout; Hepcidin; Synthetic peptides; Antimicrobial activity
摘要:
Hepcidin, a hepatic antimicrobial peptide, is a key player of the nonspecific immune system. The structure of hepcidin gene from brown trout (Bthepc) has been characterized at the molecular level. The 1158-bp mRNA generates a coding sequence (CDS) of 267 bp, which encodes an 88-amino acid protein. Molecular evolution analysis classified Bthepc to the family Salmonidae. Amino acid sequence homologies between Bthepc and hepcidin in other species such as Oncorhynchus mykiss, Salmo solar, and Hucho ...More
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